Short Courses

Fundamentals of Mass Spectrometry
O. David Sparkman, J├╝rgen H. Gross

A two-day course on the interpretation of mass spectra of organic compounds.

Starting at the introductory level, the course is intended to provide the fundamentals for an understanding of the basic principles and applications of mass spectrometry of organic molecules.

Key topics of the short course are ionization processes, the formation and interpretation of isotopic patterns, uses of high-resolution and accurate mass for molecular formula determination, and an introduction to the fragmentation pathways of odd-electron and even-electron ions.

Information regarding available mass spectral databases will be provided along with how to use them with all types of organic mass spectrometry including MS/MS data. With an emphasis on the analysis of small molecules, you will learn to systematically employ all of the above mass spectral data for compound identification and structure elucidation.

To complete the course, compact lectures on instrumentation and its common modes of operation, as well as on the basics of widespread soft ionization methods such as chemical ionization (CI), field desorption (FD) including LIFIDI, electrospray ionization (ESI), and matrix-assisted laser desorption/ionization (MALDI) and ambient MS (DESI, DART) will be included.

Methodology Lectures (about 80% of the time) plus short simple exercises to assist understanding Language and Presentation English PowerPoint

Advanced Interpretation of CID Mass Spectra from LC/MS/MS
Robert D. Voyksner

This advanced 2 day course will cover generation and interpretation of Collision Induced Dissociation (CID) mass spectra generated from positive and negative ions formed from the API techniques of electrospray, APCI or APPI.

The course will cover formation of ions, variables in CID mass spectra under tandem MS (triple quadrupole, q-TOF, ion trap) and API transport CID and interpretation of both the molecular ion and common molecular adduct ions and the product ion formed from these species after CID. The interpretation of the product ion mass spectra will be broken down into distinctive fragmentation mechanisms to aid the student to develop a systematic approach towards spectral interpretation. The fragmentation processes covered include single bond cleavage, multiple bond cleavage with charge retention and with charge migration, cyclization, ring opening fragmentation, hydrogen rearrangements, and charge remote fragmentation. The fragmentation mechanisms will be applied to both positive and negative ions. Additionally, CID product ion formation from adducts such as [M+Na]+ [M+NH4]+ and [M+F, Cl or Br]- will be covered. Each of the lectures have imbedded practical problems, which will allow a review of the various fragmentation mechanisms on a variety of compound types. The course will finish with a series of real world LC/MS/MS interpretation problems applicable to pharmaceuticals, clinical, industrial, and forensic and biochemical industry that the students will work on in groups and discuss at the end of the class.

The course is designed for the students who have completed a LC/MS Short Course or who have some working knowledge of LC/MS and want to improve their qualitative interpretation skills for problem solving in LC/MS.

The NSERC CREATE Training program in
Mass Spectrometry-enabled Science and Engineering (York University)

Courses are offered at a discount as they are linked to the CREATE program. Discounts are available to all participants.

Career Paths for Mass Spectrometry in Academia

In this course, international academic leaders in mass spectrometry will share with you the story of the evolution of their careers in academia: How they got into to the buisness, how their research programs evolved over time and their involvement in major conceptual or technical advances in their fields. The course will provide ample time for formal and informal discussion with each speaker, culminating in a panel discussion on "Maximizing success in Academic Careers in Mass Spectrometry"

Career Paths for Mass Spectrometry in Industry

In this course, leaders in industrial mass spectrometry from a broad range of multinational companies including Sanofi-Pasteur, Sciex, Waters, Maxxam, Fluidigm, Ionics and many others will share stories on: Career paths in industry, historical perspectives on the development of their company / sector, entrepreneurial stories or 'case study' industrial research projects in mass spectrometry. The course will offer ample time for formal an informal discussion with each speaker, culminating in a panel discussion on "Maximizing Success in Industrial Careers in Mass Spectrometry" and "Industry / Academic Collaborations in Industrial Mass Spectrometry"

Key Dates

  • 2016-01-01: Registration Opens
  • 2016-01-01: Abstract Submissions Start
  • 2016-05-06: Abstract Submissions for Orals Closes (extended)
  • 2016-05-20: Abstract Submissions for Posters Closes (extended)
  • 2016-05-30: Early Registration End
  • 2016-08-20: Short Courses Start
  • 2016-08-21: Conference Starts